If you live in the southwest United States or central Europe, you may be losing a year or more of your life to air pollution. Parts of China, India an...
Better together? Testing the first combination therapies for longevity
The normal mode of drug discovery is a pretty singular affair: one compound, one disease. This is enough for many traditional diseases, but when you’r...
Research roundup: Drifters in your epigenome, and more
Epigenetic markers “drift” as we age to cause unintended gene expression changes, but you might be able to slow this via caloric restricti...
In the media: Mouse mugshots, metabolic mayhem and metformin
Is a picture worth a thousand biomarkers? MouseAGE, the AI that wants to eyeball the age of rodents, thinks so. Dr. Craig Thomspon talks cancer metabo...
Longevity orthologs: How far from the apple to the tree?
Laboratories studying the biology of aging are a menagerie of creatures great and small. From unicellular yeast and nematodes, all the way up to prima...
Research roundup: Growth hormone receptor mutations in centenarians, and more
A study of centenarians finds a certain mutation of the growth hormone receptor gene is more common among men, but not women, compared to 70-year-old ...
In the media: Autophagy, APOE4 and amyloid alternatives
Had your curiosity piqued by our recent autophagy articles? Learn even more about this essential cellular process over at LEAF science! Human trials o...
No more eraserhead: Will blocking epigenetic erasers prevent Alzheimer’s disease?
Just like a well-folded sheet of paper, a tightly coiled segment of DNA doesn’t have much chance of being read. Our cells use this to their advantage,...
Pet dogs on rapamycin are pictures of health
In the lab, rapamycin is a star geroprotector. In addition to boosting lifespan even when used in late life, it’s also been found specifically t...
Metformin: Multipurpose marvel, or medical misfire?
Much rests on metformin’s shoulders: as the first drug to begin clinical trials for preventing multiple age-related diseases, it could soon become the...