The diabetes drug Metformin is handled as new anti-aging compound. But which studies actually promoted the longevity effects of Metformin?
We provide an up-to-date table with the newest studies released on Metformin supplementation:
Species | Aver. life span change [%] | Max. life span change [%] | Start of treatment | Dosage | Gender | Significance? | Reference |
M. musculus | 6 | n.m. | At middle age (8 months) | 0.1% w/w in diet (1% was toxic) | mixed | Y | Martin-Montalvo, A et al. (2013) Metformin improves healthspan and lifespan in mice. Nat Commun 4()2192 |
M. musculus | 13.1 | 16.2 | At middle age (8 months) | 100 mg/kg | Female | Y | Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. |
M. musculus | 20.8 | 10.3 | Young adults | 100 mg/kg | Female | Y | Metformin slows down aging and extends life span of female SHR mice. |
M. musculus | 5.1 | 3.9 | Young adults | 300 mg/kg | Female | Y | Protective effect of metformin on biomarkers of aging, life span and spontaneous tumorigenesis in female but not in male |
M. musculus | -13.4 | n.m. | Young adults | 300 mg/kg | Male | Y | Protective effect of metformin on biomarkers of aging, life span and spontaneous tumorigenesis in female but not in male |
R. norvegicus | 2 | 2 | Young adults (4 month) | 300 mg/kg/day | mixed | N | Smith, DL et al. (2010) Metformin supplementation and life span in Fischer-344 rats. J. Gerontol. A Biol. Sci. Med. Sci. 65(5)468-474 |