Metformin as Geroprotector

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The diabetes drug Metformin is handled as new anti-aging compound. But which studies actually promoted the longevity effects of Metformin?

We provide an up-to-date table with the newest studies released on Metformin supplementation:

Species Aver. life span change [%] Max. life span change [%] Start of treatment Dosage Gender Significance? Reference
M. musculus 6 n.m. At middle age (8 months) 0.1% w/w in diet (1% was toxic) mixed Y Martin-Montalvo, A et al. (2013) Metformin improves healthspan and lifespan in mice. Nat Commun 4()2192
M. musculus 13.1 16.2 At middle age (8 months) 100 mg/kg Female Y Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
M. musculus 20.8 10.3 Young adults 100 mg/kg Female Y Metformin slows down aging and extends life span of female SHR mice.
M. musculus 5.1 3.9 Young adults 300 mg/kg Female Y Protective effect of metformin on biomarkers of aging, life span and spontaneous tumorigenesis in female but not in male
M. musculus -13.4 n.m. Young adults 300 mg/kg Male Y Protective effect of metformin on biomarkers of aging, life span and spontaneous tumorigenesis in female but not in male
R. norvegicus 2 2 Young adults (4 month) 300 mg/kg/day mixed N Smith, DL et al. (2010) Metformin supplementation and life span in Fischer-344 rats. J. Gerontol. A Biol. Sci. Med. Sci. 65(5)468-474

 

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