When Americans 50 years ago envisioned the perfect youthful physique, the trim, athletic body would surely have sported a sun-baked complexion. And wh...
Rapamycin: An impressive geroprotector with a few potential flaws
If any drug has performed consistently and unequivocally well in anti-aging trials, it’s rapamycin. Dr. Matt Kaeberlein’s Dog Aging Project is among t...
Your DNA ages too: Genomic instability as a hallmark of aging
Part of the Hallmarks of Aging series. The cells in our bodies are constantly churning out proteins and other structures, built according to the bluep...
Intriguing results for Thioflavin T, but reproducibility is the real winner in CITP
Bolstering results from a 2011 study, a team led by Buck Institute researcher Gordon Lithgow found the compound Thioflavin T to increase the lifespan ...
The hallmarks of aging, in plain English
Part of the Hallmarks of Aging series. Did you know you have two different ages? The obvious one is chronological age, or the number of years since yo...
Live slow, die old: Mounting evidence for caloric restriction in humans
Let’s say you wanted to hear a first-hand story of ordinary life 100 years ago. Where might you go to find a storyteller? Maybe you want to hear as ma...
Flip this epigenome: Making old mice good as new
Scientists at the Salk Institute for Biological Studies knew it could be done in principle–all you had to do to erase the telltale signs of agin...
TAME: Teaching old diabetes drugs new tricks
In 2014, researchers behind a study comparing two diabetes drugs were surprised to find that not only did patients on one of the medications have high...
Aging Demystified
Modern health and medicine have all but eradicated the poxes and plagues that fixed the life expectancy of a person in the 19th century at 40 years ol...