In the lab, rapamycin is a star geroprotector. In addition to boosting lifespan even when used in late life, it’s also been found specifically t...
Metformin: Multipurpose marvel, or medical misfire?
Much rests on metformin’s shoulders: as the first drug to begin clinical trials for preventing multiple age-related diseases, it could soon become the...
Metformin: Stress versus strength
Imagine pulling a rubber band taut and flicking it with your finger. As long as you don’t flick too hard, the rubber band will always snap back into i...
Metformin: Can you have your cake and eat it, too?
When Americans 50 years ago envisioned the perfect youthful physique, the trim, athletic body would surely have sported a sun-baked complexion. And wh...
Dead to the world for longer life
Sleeping is so easy you could, well, do it in your sleep. For now, anyway – you may not always have it so good. By our twilight years many of us...
Rapamycin: An impressive geroprotector with a few potential flaws
If any drug has performed consistently and unequivocally well in anti-aging trials, it’s rapamycin. Dr. Matt Kaeberlein’s Dog Aging Project is among t...
Best friends forever: Matt Kaeberlein on helping dogs live longer
Dr. Matt Kaeberlein, an aging researcher and professor at the University of Washington, is the director of the Dog Aging Project. This two part progra...
Intriguing results for Thioflavin T, but reproducibility is the real winner in CITP
Bolstering results from a 2011 study, a team led by Buck Institute researcher Gordon Lithgow found the compound Thioflavin T to increase the lifespan ...
Live slow, die old: Mounting evidence for caloric restriction in humans
Let’s say you wanted to hear a first-hand story of ordinary life 100 years ago. Where might you go to find a storyteller? Maybe you want to hear as ma...
Flip this epigenome: Making old mice good as new
Scientists at the Salk Institute for Biological Studies knew it could be done in principle–all you had to do to erase the telltale signs of agin...