Dr. Michael Ristow, a professor of energy metabolism at ETH Zurich, bases much of his research into aging on a premise that many of us will find surpr...
Oxidative stress response: One of the many jobs of tumor-suppressor p53
At its most dramatic, oxidative stress can rend DNA in two and predispose cells to mutations that ultimately result in cancer. But the less bombastic ...
What’s eating you?
Many people think of sleep almost as if it were a state of suspended animation, like turning off a computer so that it can cool down. But while your c...
Does the sandman retire? Why old people sleep poorly
If grandpa nods off in the middle of dinner, it’s not because you’re boring him. The aging process isn’t very kind to our ability to get to sleep at n...
Metformin: Stress versus strength
Imagine pulling a rubber band taut and flicking it with your finger. As long as you don’t flick too hard, the rubber band will always snap back into i...
Metformin: Can you have your cake and eat it, too?
When Americans 50 years ago envisioned the perfect youthful physique, the trim, athletic body would surely have sported a sun-baked complexion. And wh...
The joy of scientific discovery, converging disease mechanisms, and failures of communication: Dr Gordon Lithgow on the past and present of geroscience (part II)
Dr. Gordon Lithgow of the Buck Institute for Research on Aging, who spoke to us recently about the Caenorhabditis Intervention Testing Program, talks ...
Dr. Gordon Lithgow on conflicting results in longevity studies, the origins of the CITP, and more (part I)
Dr. Gordon Lithgow got in on the ground floor of aging research in the lab that discovered the first anti-aging mutation, age-1, and has spent the 25 ...
Rapamycin: An impressive geroprotector with a few potential flaws
If any drug has performed consistently and unequivocally well in anti-aging trials, it’s rapamycin. Dr. Matt Kaeberlein’s Dog Aging Project is among t...
Your DNA ages too: Genomic instability as a hallmark of aging
Part of the Hallmarks of Aging series. The cells in our bodies are constantly churning out proteins and other structures, built according to the bluep...