Sebastian Aguiar, geroscientist and Venture Fellow at Apollo Ventures, delivers the Lord Florey Lecture at Lincoln College, Oxford in November 2018. H...
Spermidine fuels the self-eating machine
Introducing spermidine Present in all mammalian cells, polyamines are positively charged ions that are vital for cellular growth, survival, and divisi...
The Hallmarks of Aging: Loss of Proteostasis
Part of a series on the Hallmarks of Aging. Proteins don’t do everything in your body, but it’s fair to say they control everything. What they don’t d...
Research roundup: The importance of energy in Alzheimer’s, and more
Since the world of Alzheimer’s therapeutics hasn’t seen much practical benefit from targeting harmful proteins like amyloid-beta, maybe ot...
FOXO vs. a harbinger of neurodegeneration
Long before the usual physiological signs, the withering of neurons and the gradual atrophy of the brain, that tip doctors off to the presence of a ne...
Breaking skin: Tiny troublemakers in epidermal aging
That weathered, pruny exterior loved by photographers and loathed by nearly everyone else is, along with gray hair, perhaps the most easily recognizab...
A bountiful harvest of research
Keeping one eye on your calories, and the other on that delicious-looking pumpkin pie? Don’t worry–your Thanksgiving sins probably wonR...
Research roundup: The Hippo in your heart, and more
The Hippo pathway controls cellular regeneration, so why not modify it to heal the heart after the scarring caused by a heart attack? Six weeks later,...
Longevity orthologs: How far from the apple to the tree?
Laboratories studying the biology of aging are a menagerie of creatures great and small. From unicellular yeast and nematodes, all the way up to prima...
In the media: Autophagy, APOE4 and amyloid alternatives
Had your curiosity piqued by our recent autophagy articles? Learn even more about this essential cellular process over at LEAF science! Human trials o...