Part III of III in a series on the evolution of aging. (Part I, Part II) If all you had to go on was our genomes, you’d surely conclude that humans an...
Research roundup: The importance of energy in Alzheimer’s, and more
Since the world of Alzheimer’s therapeutics hasn’t seen much practical benefit from targeting harmful proteins like amyloid-beta, maybe ot...
FOXO vs. a harbinger of neurodegeneration
Long before the usual physiological signs, the withering of neurons and the gradual atrophy of the brain, that tip doctors off to the presence of a ne...
The Hallmarks of Aging: Epigenetic Alterations
All cells in your body have the same DNA, yet they express different proteins and do different things. How does that happen? Various alterations in y...
A bountiful harvest of research
Keeping one eye on your calories, and the other on that delicious-looking pumpkin pie? Don’t worry–your Thanksgiving sins probably wonR...
Better together? Testing the first combination therapies for longevity
The normal mode of drug discovery is a pretty singular affair: one compound, one disease. This is enough for many traditional diseases, but when you’r...
Research roundup: Drifters in your epigenome, and more
Epigenetic markers “drift” as we age to cause unintended gene expression changes, but you might be able to slow this via caloric restricti...
What’s eating you?
Many people think of sleep almost as if it were a state of suspended animation, like turning off a computer so that it can cool down. But while your c...
Healthspan: Is life extension a Faustian bargain?
If you could buy a few more years of life by sacrificing some of your health, would you? When would the trade stop being worth it to you–when yo...
Metformin: Can you have your cake and eat it, too?
When Americans 50 years ago envisioned the perfect youthful physique, the trim, athletic body would surely have sported a sun-baked complexion. And wh...