LEAF takes an incisive look at the popular “eternal snoozefest” view of life extension and knocks down that shaky extrapolation from elder...
Michael Fossel on telomerase therapy in cancer, Alzheimer’s, and more
Last week we heard the theoretical side of Dr. Michael Fossel’s mission to bring aging to its knees, and why his chosen point of attack was on t...
Research roundup: The Hippo in your heart, and more
The Hippo pathway controls cellular regeneration, so why not modify it to heal the heart after the scarring caused by a heart attack? Six weeks later,...
Più mosso, Maestro! An interview in the key of telomere with Dr. Michael Fossel
With three decades of experience as a professor of clinical medicine under his belt, Dr. Michael Fossel takes a fundamentally pragmatic approach to ta...
In the media: Telomeres, translation, and treatment
“All of this time I had been thinking about telomere maintenance in terms of the minuscule cellular molecular structures that they are, and the ...
Research roundup: Untangling ApoE4, and more
It’s been known for ages that individuals with two ApoE4 alleles were virtually destined to develop Alzheimer’s, but its link with the hal...
Media roundup: Pollution, priorities and press
If you live in the southwest United States or central Europe, you may be losing a year or more of your life to air pollution. Parts of China, India an...
Better together? Testing the first combination therapies for longevity
The normal mode of drug discovery is a pretty singular affair: one compound, one disease. This is enough for many traditional diseases, but when you’r...
Research roundup: Drifters in your epigenome, and more
Epigenetic markers “drift” as we age to cause unintended gene expression changes, but you might be able to slow this via caloric restricti...
In the media: Mouse mugshots, metabolic mayhem and metformin
Is a picture worth a thousand biomarkers? MouseAGE, the AI that wants to eyeball the age of rodents, thinks so. Dr. Craig Thomspon talks cancer metabo...